Contamination has vital role in deciding the quality of cotton apart from essential properties such as length, strength, fineness. Contamination of raw cotton can take place at every step i.e. from the farm picking to the ginning stage. Contamination, even if it is a single foreign fibre, can lead to the downgrading of yarn, fabric or garments or even the total rejection of an entire batch and can cause irreparable harm to the relationship between growers, ginners, merchants, spinner and textile and clothing mills. An International Textile Manufacturers Federation (ITMF) reported that claims due to contamination amounted to between 1.4 – 3.2% of total sales of 100% cotton and cotton blended yarns. The main aim of this paper is to give a perspective about the contaminants and its types, causes, effects, statistics of contaminants, preventive measures to eliminate contaminants and contamination cleaning methods.